中药材与植物科学系

沈勇





 

 

 


姓名沈勇

职称教授

导师:硕士生导师

专业药物化学

邮箱pharmsy@sina.com

 

  教育及工作经历

  2007.08-2010.07:中国科学院昆明植物研究所,博士,药物化学专业;

  2001.08-2004.07:云南中医学院,硕士研究生,中药学专业;

  1997.08-2001.07:云南中医学院,大学本科,中药制药专业;

  2010-至今:必威betway中国官方网站,主要从事科研及教学工作;

  2015-2018年:中国科学院昆明植物研究所,健康品与功能护肤品研发中心;

  2010-2015年:昆明滇虹药业集团研究所,高级研发顾问;

  2004-2007年:昆明滇虹药业研究所,主要从事新药研发工作,项目主管;

 

  研究方向

  中药学和功能产品研发


  奖励与荣誉

  云南十一种药用乌头属植物活性成分二萜生物碱的发现及活性评价,云南省科学技术奖,三等奖,2020.11        


  研究项目

  国家自然科学基金项目,3株直缘乌头内生真菌次生代谢产物及其抗炎活性研究,2014/01-2017/12,项目主持人。

  中国科学院昆明植物研究所,特色研究所项目,消化功能保健食品的研究与开发,2016/07-2018/12,项目主持人。

  红河群鑫石斛种植有限公司,石斛面霜和洗发水研究与开发,2015/07-2017/12,项目主持人。

  昆明加加宁生物制品有限公司,功能性食品及制药工业的研究与开发,2016/07-2018/12,项目主持人。

  国家自然科学基金项目,乌头属植物酚苷类成分的发现及抗HBV活性研究,2020/01 -2023/12,项目主持人。


  代表性论文

  Da-Ke Zhao, Ya-Na Shi, Li Liu, Peng-Zhang Ji, Chun-Lin Long, Yong Shen*, Edward J. Kennelly. Identification of potential biomarkers from Aconitum carmichaelii, a traditional Chinese Medicine, using a metabolomics approach. Planta Medica, 2018, 84, 434-441.

  Da-Ke Zhao, Yong Shen(并列第一), Ya-Na Shi, Xing-Qiao Shi, Qin Qiao, Shu-Hui Zi, Er-Qiang Zhao, Di-Qiu Yu, Edward J. Kennelly. Probing the transcriptome of Aconitum carmichaelii reveals the candidate genes associated with the biosynthesis of the toxic aconitine-type C19-diterpenoid alkaloids. Phytechemistry, 2018, 152, 113-124.

  Xiao-Yan Duan, Da-Ke Zhao, Yong Shen*. Two new bis-C20-diterpenoid alkaloids with anti-inflammation activity from Aconitum bulleyanum. J. Asian Nat. Prod. Res. 2019, 21, 323-330.

  Wang-Yan Liu, Dan He, Da-Ke Zhao, Yan-Ping Chen, Yong Shen*. Four new C19-diterpenoid alkaloids from the roots of Aconitum ouvrardianum. J. Asian Nat. Prod. Res. 2019, 21, 9-16.

  Dan He, Wang-Yan Liu, Jiao Xiong, Jun-Ju Xu, Yong Shen*. Four new C19-diterpenoid alkaloids from Aconitum hemsleyanum var. circinatum. J. Asian Nat. Prod. Res. 2019, 21, 833-841.

  Qiu-Xia WangShi-Cheng Shao, Yuan Su, Xue-Li Hu, Yong Shen*, Da-Ke Zhao. A novel case of autogamy and cleistogamy in Dendrobium wangliangii: A rare orchid distributed in the dry‐hot valley. Ecology and Evolution, 2019, 9, 12906-12914.

  Da-Ke Zhao, Ya-Na Shi, Harini Anandhi Senthilkumar, Qin Qiao, Qiu-Xia Wang, Yong Shen*, Guang-Wan Hu. Enriched networks ‘nucleoside/nucleotide and ribonucleoside/ ribonucleotide metabolic processes’ and ‘response to stimulus’ potentially conferred to drought adaptation of the epiphytic orchid Dendrobium wangliangii. Physiol. Mol. Biol. Plants. 2019, 25, 31-45.

  Da-Ke Zhao, Yang Yu, Yong Shen(并列第一), Qin Liu, Zhi-Wei Zhao, Ramaswamy Sharma, Russel J. Reiter. Melatonin Synthesis and Function: Evolutionary History in Animals and Plants, Front Endocrinol. 2019, 10, 249.

  Yong Shen, Wen-Juan Liang, Ya-Na Shi, Edward J. Kennelly, Da-Ke Zhao. Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids. Nat. Prod. Rep. 2020, 37, 763-796.

  Chong-Kang Yang, Jiong Xiong, Lian Zhagn, Wen-Juan Liang, Yong Shen*. Two new dammarane-type triterpenoids from the steamed roots of Panax notoginseng. J. Asian Nat. Prod. Res. 2021, 23, 961-967.

  Chong-Kang Yang, Jiong Xiong, Yong Shen*. Two new dammarane-type triterpenoids from the stems and leaves of Panax notoginseng. J. Asian Nat. Prod. Res. 2021, 23, 341-347.

  Jiang-Rui He, Li-Mei Zhang, Hong-Bo Lou, Dan Lv, Ai-Xue Zuo, Yong Shen*. Two new bis-diterpenoid alkaloids from Aconitum weixiense, J. Asian Nat. Prod. Res. 2023, 25, 842-848.


  专利及标准

  沈勇、熊娇。以化合物lipoyunaconitine 为活性成分的抗肿瘤药物组合物及其应用。申请号:ZL 201710294128.7

  沈勇、熊娇。人参皂苷Rg3,三七皂苷Ft1及其组合物在制备治疗前列腺增生方面的应用。申请号:ZL 202211160833.5